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Symbol
Name
ID

Lmna
lamin A
MGI:96794

Phenotype annotations related to adipose tissue

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes	Increased facial adipose tissue	Increased adipose tissue around the neck	Reduced subcutaneous adipose tissue	Adipose tissue loss	Absence of subcutaneous fat	Loss of subcutaneous adipose tissue in limbs	Loss of truncal subcutaneous adipose tissue	Increased intraabdominal fat	Increased intramuscular fat	Lipodystrophy	Lipoatrophy
Disease(s) Associated with LMNA	Increased facial adipose tissue	Increased adipose tissue around the neck	Reduced subcutaneous adipose tissue	Adipose tissue loss	Absence of subcutaneous fat	Loss of subcutaneous adipose tissue in limbs	Loss of truncal subcutaneous adipose tissue	Increased intraabdominal fat	Increased intramuscular fat	Lipodystrophy	Lipoatrophy
dilated cardiomyopathy 1A
dilated cardiomyopathy-hypergonadotropic hypogonadism syndrome
Emery-Dreifuss muscular dystrophy
familial partial lipodystrophy type 2
mandibuloacral dysplasia type A lipodystrophy
progeria
Werner syndrome

Mouse Phenotypes

adipose tissue phenotype

absent subcutaneous adipose tissue

decreased subcutaneous adipose tissue amount

decreased white adipose tissue amount

decreased abdominal adipose tissue amount

decreased total body fat amount

increased brown adipose tissue mass

abnormal fat cell differentiation

abnormal inguinal fat pad morphology

increased renal fat pad weight

increased abdominal fat pad weight

decreased percent body fat/body weight

decreased white adipose tissue mass

Availability

Mouse Genotype

Lmna^Dhe/Lmna^Dhe

Lmna^{Gt(S7-1F1)Sor}/Lmna^{Gt(S7-1F1)Sor}

Lmna^tm1.1Otin/Lmna^tm1.1Otin

Lmna^tm1Lgf/Lmna^tm1Lgf

Lmna^tm1Stw/Lmna^tm1Stw

Lmna^tm2.1Gbon/Lmna^tm2.1Gbon

Lmna^tm2Stw/Lmna^tm2Stw

Lmna^tm3Lgf/Lmna^tm3Lgf

Lmna^tm8Lgf/Lmna^tm8Lgf

*

Lmna^Dhe/Lmna⁺

Lmna^em1Fenz/Lmna⁺

*

Lmna^tm1Lgf/Lmna⁺

Lmna^tm1Stw/Lmna⁺

*

Lmna^tm3Lgf/Lmna⁺

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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